Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles.

نویسندگان

  • Shuqing He
  • Kristina Krippes
  • Sandra Ritz
  • Zhijun Chen
  • Andreas Best
  • Hans-Jürgen Butt
  • Volker Mailänder
  • Si Wu
چکیده

Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Manipulating pH using near-infrared light assisted by upconverting nanoparticles.

Near-infrared light can be used to manipulate the pH of aqueous solutions by using upconverting nanoparticle-assisted photocleavage of a ruthenium complex photobase. Upconverting nanoparticles and the photobase were also introduced into a pH-responsive hydrogel, in which near-infrared irradiation induced swelling of the hydrogel.

متن کامل

Energy transfer between amphiphilic porphyrin polymer shells and upconverting nanoparticle cores in water-dispersible nano-assemblies.

The synthesis of water-dispersible nano-assemblies containing upconverting nanoparticles (UCNPs) and porphyrin molecules using a one-pot method is described. When the nano-assemblies are excited by 980 nm near-infrared light, the intensity of the 'green emission' band of the UCNP is reduced due to a combination of Föster Resonace Energy Transfer (FRET) and emission-reabsorption. This process is...

متن کامل

Near-infrared photochemistry at interfaces based on upconverting nanoparticles.

Near-infrared (NIR) light is better suited than ultraviolet (UV) light for biomedical applications because it penetrates deeper into tissue and causes less photodamage to biological systems. The use of NIR light to control biointerfaces has attracted increasing interest. Here, we review NIR photoreactions at interfaces based on upconverting nanoparticles (UCNPs). UCNPs can convert NIR light to ...

متن کامل

Application of near-infrared light intensity to determine normal and cancerous breast vessel contrast by gold nanoparticles

Objective(s): A novel technique for the early diagnosis of breast cancer involves the use of nanoparticles (NPs). The present study aimed to use gold NPs to assess the variations in light source transfer intensity. Materials and Methods: Blood samples with hemoglobin (Hb) concentrations of ×1, ×2, and ×4 were used to simulate normal and cancerous conditions in the breast. Spherical gold N...

متن کامل

Upconversion Nanoparticles: A Versatile Solution to Multiscale Biological Imaging

Lanthanide-doped photon upconverting nanomaterials are emerging as a new class of imaging contrast agents, providing numerous unprecedented possibilities in the realm of biomedical imaging. Because of their ability to convert long-wavelength near-infrared excitation radiation into shorter-wavelength emissions, these nanomaterials are able to produce assets of low imaging background, large anti-...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 51 2  شماره 

صفحات  -

تاریخ انتشار 2015